Welcome To Dr. Changchun Liu’s Synthetic Biology and Smart Medical Device Laboratory


Paradigm shifts in biomedical field often arise from innovations in tools and measurement methods. Our research group is interested in applying interdisciplinary approaches to develop new tools and methods to solve current challenges in life sciences, such as disease diagnostics, medical therapeutics, as well as personalized medicine. Our current research focuses on the integration of micro- and nanotechnology with biology and medicine, and their biomedical applications. Our research philosophy is “Interdisciplinary Integration and Innovation (I3)”. We are a diverse team of scientists & engineers with broad expertise spanning molecular biology, CRISPR technology, synthetic biology and chemistry to engineering.

We are seeking highly talented and motivated individuals (e.g., postdoc, graduate, and undergraduate) from different disciplinary backgrounds (e.g., biology, chemistry, biomedicine, and engineering (i.e., mechanical, electronic, biomedical, material)). Please see the positions available. We welcome inquiries about positions with a cover letter and curriculum vitae by contacting Dr. Changchun Liu via email (chaliu@uchc.edu).

Latest Lab News


August 2020: Xiong’s paper entitled “Ultrasensitive and visual detection of SARS-CoV-2 using all-in-one dual CRISPR-Cas12a assay” is accepted by Nature Communications. Congratulations! After Developing CRISPR-based Diagnostic Test for Infectious Diseases, UConn Researchers Validate Clinical Feasibility for COVID-19 Testing at Point of Care.

August 2020: Liu lab received NIH R61 Award on HIV-self testing. UConn Researcher Developing ‘Blood-to-Answer’ Method for Early HIV Detection.

July 2020: Ziyue Li passed his PhD Qualifying exam. Congratulations!.

June 2020: Dr. Changchun Liu was invited to give a talk at The Talks. Mobile Point-of-Care AIOD-CRISPR-based COVID-19 Diagnostics.

June 2020: Liu lab received NIH R01 supplement Award on COVID-19 diagnostics.

April 2020: Dr. Changchun Liu had an Audio Interview with Henry Stewart Talks: A novel AIOD-CRISPR system for diagnosis of SARS-CoV-2.

March 2020: Dr. Changchun Liu had an interview with Technology Networks. A Point-of-Care CRISPR-based COVID-19 Diagnostic Could Be on the Horizon.

March 2020: Xiong’s work on AIOD-CRISPR technology was featured on  UConn Today. Amidst COVID-19 Outbreak, UConn Researchers Working on Simple, Low-Cost CRISPR-based Diagnostic Test for Infectious Diseases.

February 2020: Liu lab received a sub-award of NIH U01 in collaboration with Dr.  Rachael Clark at Harvard Medical School.

Latest Publications


Xiong Ding, Kun Yin, Ziyue Li, Rajesh V. Lalla, Enrique Ballesteros, Maroun M. Sfeir, Changchun Liu, Ultrasensitive and visual detection of SARS-CoV-2 using all-in-one dual CRISPR-Cas12a assay, Nature Communications, 2020, 11, 4711. DOI: https://doi.org/10.1038/s41467-020-18575-6

Kun Yin, Vikram Pandian, Karteek Kadimisetty, Xin Zhang, Carlos Ruiz, Kumarasen Cooper, Changchun Liu, Real-time colorimetric Quantitative Molecular Detection of infectious Diseases on Smartphone-based Diagnostic platform, Scientific Reports, 2020, 10, 9009. DOI: https://doi.org/10.1038/s41598-020-65899-w

Kun Yin, Xiong Ding, Ziyue Li, Hui Zhao, Kumarasen Cooper, Changchun Liu, Dynamic aqueous multiphase reaction system for one-pot CRISPR-Cas12a based ultrasensitive and quantitative molecular diagnosis, Anal. Chem. 2020, 92, 12, 8561–8568.

Carlos Ruiz, Karteek Kadimisetty, Kun Yin, Michael G Mauk, Hui Zhao, Changchun Liu, Fabrication of Hard–Soft Microfluidic Devices Using Hybrid 3D Printing, Micromachines, 2020, 11(6), 567; https://doi.org/10.3390/mi11060567


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Contact Us

Professor Changchun Liu

Biomedical Engineering Department

University of Connecticut, UConn Health

263 Farmington Avenue

Farmington, CT 06030, USA

Office:              Room L6083

Phone:             860-679-2565

Email:             chaliu@uchc.edu

Website:          https://smds.engr.uconn.edu/