Welcome to Synthetic Biology and Smart Medical Device Laboratory

Paradigm shifts in biomedical fields often arise from innovations in tools and measurement methods. Our research group is interested in applying interdisciplinary approaches to develop new tools and methods to solve current challenges in life sciences, such as disease diagnostics, medical therapeutics, as well as personalized medicine. Our current research focuses on the integration of micro- and nanotechnology with biology and medicine, and their biomedical applications. Our research philosophy is “Interdisciplinary, Integration and Innovation (I3)”.

We are seeking highly talented and motivated individuals (e.g., postdoc, graduate, and undergraduate) from different disciplinary backgrounds (e.g., biology, chemistry, biomedicine, and engineering (e.g., mechanical, electronic, biomedical). Please see the positions available. We welcome inquiries about positions with a cover letter and CV by contacting Dr. Changchun Liu via email (chaliu@uchc.edu).

Latest Lab News

August 2023: Ziyue Li successfully defended his PhD thesis. Ziyue has accepted an Associate Professor position at the Zhejiang University School of Medicine, China. Congratulations to Ziyue! We wish him the best of luck in his career journey!

April 2023: Dr. Naoki Uno, a postdoc researcher at our lab, has accepted an Associate Professor position at the department of medical virology, Nagasaki University, Japan. Congratulations to Dr. Uno! We wish him the best of luck in his career journey!

March 2023: Our work on HIV test device has been featured by Connecticut Public Radio: Testing for HIV can be costly and time-consuming. A new device in development seeks to change that.

March 2023: Our research on CRISPR-mediated cascade reaction biosensor has been featured by UConn Today. UConn Researcher Develops Simple, Affordable HIV Testing Device.

April 2022: Uyanga Ganbaatar passed her Master defense successfully. Congratulations to Uyanga! We wish her the best of luck in her career journey!

February 2022: Our research work has been featured by Connecticut Post. UConn professor adapts cancer test to detect COVID-19 at home.


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Latest Publications

Zhengyang Jia, Ziyue Li, Changchun Liu, CRISPR-powered Biosensing Platform for Quantitative Detection of Alpha-fetoprotein by a Personal Glucose Meter, Sensors and Actuators B: Chemical, 2023, https://doi.org/10.1016/j.snb.2023.133994

Naoki Uno, Ziyue Li, Lori Avery, Maroun M. Sfeir, and Changchun Liu, CRISPR gel: A one-pot biosensing platform for rapid and sensitive detection of HIV viral RNA, Analytica Chimica Acta, 2023, https://doi.org/10.1016/j.aca.2023.341258

Ziyue Li, Naoki Uno, Xiong Ding, Lori Avery, David Banach, and Changchun Liu, Bioinspired CRISPR-Mediated Cascade Reaction Biosensor for Molecular Detection of HIV Using a Glucose Meter, ACS Nano, 2023, https://pubs.acs.org/doi/10.1021/acsnano.2c12754.

Naoki Uno, Ziyue Li, and Changchun Liu, Single-tube One-step Gel-based RT-RPA/PCR for Highly Sensitive Molecular Detection of HIV Virus, Analyst, 2023, DOI: 10.1039/D2AN01863B.

Uyanga Ganbaatar and Changchun Liu, NEXT CRISPR: An enhanced CRISPR-based nucleic acid biosensing platform using extended crRNA, Sensors and Actuators B: Chemical, 2022, https://doi.org/10.1016/j.snb.2022.132296

Ziyue Li, Xiong Ding, Kun Yin, Lori Avery, Enrique Ballesteros, and Changchun Liu, Instrument-Free, CRISPR-based Diagnostics of SARS-CoV-2 using Self-Contained Microfluidic SystemBiosensors and Bioelectronics, 2022, 199, 113865, https://doi.org/10.1016/j.bios.2021.113865.

Xiong Ding, Ziyue Li, Lori Avery, Enrique Ballesteros, Rohit Makol, and Changchun Liu, pH-EVD: A pH-Paper-based Extraction and Visual Detection System for Instrument-free SARS-CoV-2 Diagnostics, Advanced NanoBiomed Research, 2021, http://doi.org/10.1002/anbr.202100101.

Jiongyu Zhang and Changchun Liu, CRISPR-Powered DNA Computing and Digital Display, ACS Synthetic Biology, 2021, https://doi.org/10.1021/acssynbio.1c00431

Xiong Ding, Ziyue Li, and Changchun Liu, Monolithic, 3D-Printed Lab-on-Disc Platform for Multiplexed Molecular Detection of SARS-CoV-2, Sensors and Actuators B: Chemical, 2021, https://doi.org/10.1016/j.snb.2021.130998


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Contact Us

Professor Changchun Liu

Biomedical Engineering Department

University of Connecticut, UConn Health

263 Farmington Avenue

Farmington, CT 06030, USA

Office:              Room L6083

Phone:             860-679-2565

Email:             chaliu@uchc.edu

Website:          https://smds.engr.uconn.edu/