Welcome to Synthetic Biology and Smart Medical Device Laboratory
Paradigm shifts in biomedical fields often arise from innovations in tools and measurement methods. Our research group is interested in applying interdisciplinary approaches to develop new tools and methods to solve current challenges in life sciences, such as disease diagnostics, medical therapeutics, as well as personalized medicine. Our current research focuses on the integration of micro- and nanotechnology with biology and medicine, and their biomedical applications. Our research philosophy is “Interdisciplinary, Integration and Innovation (I3)”.
We are seeking highly talented and motivated individuals (e.g., postdoc, graduate, and undergraduate) from different disciplinary backgrounds (e.g., biology, chemistry, biomedicine, and engineering (e.g., mechanical, electronic, biomedical). Please see the positions available. We welcome inquiries about positions with a cover letter and CV by contacting Dr. Changchun Liu via email (chaliu@uchc.edu).
Latest Lab News
March 2024: Our research on CRISPR-powered keyword search engine in DNA data storage has been featured by UConn Today. Searching for Data in DNA with CRISPR.
March 2024: Jiongyu’s paper entitled “CRISPR-powered quantitative keyword search engine in DNA data storage” has been accepted for publication in Nature Communications. Congratulations!
November 2023: Our research on asymmetric CRISPR assay has been featured by UConn Today. Researchers Improve Efficacy and Efficiency of CRISPR Diagnostic Technology.
November 2023: Jeong’s paper entitled “Asymmetric CRISPR enabling cascade signal amplification for nucleic acid detection by competitive crRNA” has been accepted for publication in Nature Communications. Congratulations!
August 2023: Ziyue Li successfully defended his PhD thesis. Ziyue has accepted an Associate Professor position at the Zhejiang University School of Medicine, China. Congratulations to Ziyue! We wish him the best of luck in his career journey!
April 2023: Dr. Naoki Uno, a postdoc researcher at our lab, has accepted an Associate Professor position at the department of medical virology, Nagasaki University, Japan. Congratulations to Dr. Uno! We wish him the best of luck in his career journey!
Selected Publications
Xiong Ding, Kun Yin, Ziyue Li, Rajesh V. Lalla, Enrique Ballesteros, Maroun M. Sfeir, and Changchun Liu, Ultrasensitive and visual detection of SARS-CoV-2 using all-in-one dual CRISPR-Cas12a (AIOD-CRISPR) assay, Nature Communications, 2020, 11, 4711. https://doi.org/10.1038/s41467-020-18575-6.
Jeong Moon and Changchun Liu, Asymmetric CRISPR enabling cascade signal amplification for nucleic acid detection by competitive crRNA, Nature Communications, 2023, 14, 7504. https://doi.org/10.1038/s41467-023-43389-7.
Ziyue Li, Naoki Uno, Xiong Ding, Lori Avery, David Banach, and Changchun Liu, Bioinspired CRISPR-Mediated Cascade Reaction Biosensor for Molecular Detection of HIV Using a Glucose Meter, ACS Nano, 2023, https://pubs.acs.org/doi/10.1021/acsnano.2c12754.
Jiongyu Zhang, Ziyue Li, Chong Guo, Xin Guan, Lori Avery, David Banach, and Changchun Liu, Intrinsic RNA Targeting Triggers Indiscriminate DNase Activity of CRISPR-Cas12a, Angewandte Chemie International Edition, 2024, DOI: 10.1002/anie.202403123
Jiongyu Zhang, Chengyu Hou and Changchun Liu, CRISPR-powered quantitative keyword search engine in DNA data storage, Nature Communications, 2024, 15, 2376. https://doi.org/10.1038/s41467-024-46767-x
Ziyue Li, Shuo Zhang, Jiongyu Zhang, Lori Avery, David Banach, Hui Zhao, and Changchun Liu, Palm-sized Lab-in-a-Magnetofluidic Tube Platform for Rapid and Sensitive Virus Detection, Advanced Science, 2024, DOI:10.1002/advs.202310066
Contact Us
Professor Changchun Liu
Biomedical Engineering Department
University of Connecticut, UConn Health
263 Farmington Avenue
Farmington, CT 06030, USA
Office: Room L6083
Phone: 860-679-2565
Email: chaliu@uchc.edu
Website: https://smds.engr.uconn.edu/