Welcome to Synthetic Biology and Smart Medical Device Laboratory

Paradigm shifts in biomedical field often arise from innovations in tools and measurement methods. Our research group is interested in applying interdisciplinary approaches to develop new tools and methods to solve current challenges in life sciences, such as disease diagnostics, medical therapeutics, as well as personalized medicine. Our current research focuses on the integration of micro- and nanotechnology with biology and medicine, and their biomedical applications. Our research philosophy is “Interdisciplinary Integration and Innovation (I3)”. We are a diverse team of scientists & engineers with broad expertise spanning biology, CRISPR technology, synthetic biology and chemistry to engineering.

We are seeking highly talented and motivated individuals (e.g., postdoc, graduate, and undergraduate) from different disciplinary backgrounds (e.g., biology, chemistry, biomedicine, and engineering (e.g., mechanical, electronic, biomedical)). Please see the positions available. We welcome inquiries about positions with a cover letter and CV by contacting Dr. Changchun Liu via email (chaliu@uchc.edu).

Latest Lab News

September 2021: Our research project on enhanced N95 mask protection is featured by UConn Today. UConn Health Researcher Focuses on Enhanced N95 Mask Protection.

August 2021: Dr. Xiong Ding, a postdoc researcher at our lab, has accepted a Professor position at Southeast University. Congratulations to Dr. Ding! We wish him the best of luck in his career journey!

July 2021: Jiongyu Zhang passed his PhD Qualifying exam. Congratulations!

June 2021: Our article “Autonomous Lab-on-Paper for Multiplexed, CRISPR-based Diagnostics of SARS-CoV-2” has been featured by UConn Today. UConn Engineer Develops Lab-on-Paper SARS-CoV-2 Diagnostic by CRISPR.

June 2021: Our article “Autonomous Lab-on-Paper for Multiplexed, CRISPR-based Diagnostics of SARS-CoV-2” has been featured by News Medical Life Sciences. Scientists develop low-cost lab-on-paper device for rapid and accurate detection of SARS-CoV-2.

June 2021: Our article "Autonomous Lab-on-Paper for Multiplexed, CRISPR-based Diagnostics of SARS-CoV-2" has been selected as one of "Lab on a Chip HOT Articles 2021" published in Lab on a Chip. Congratulations to Kun and everyone involved!

April 2021: Dr. Changchun Liu has received the Outstanding Researcher Award for 2020 from University of Connecticut School of Dental Medicine. Congratulations to Dr. Liu!

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Latest Publications

Zhiheng Xu, Xiong Ding, Kun Yin, Ziyue Li, Joan A Smyth, Maureen B Sims, Holly A McGinnis, Changchun Liu, TickPhone App: A Smartphone Application for Rapid Tick Identification Using Deep Learning, Applied Sciences, 2021, 11(16), 7355

Ziyue Li, Xiong Ding, Kun Yin, Zhiheng Xu, Kumarasen Cooper, Changchun Liu, Electric Field-Enhanced Electrochemical CRISPR Biosensor for DNA Detection, Biosensors and Bioelectronics, 2021, https://doi.org/10.1016/j.bios.2021.113498

Kun Yin, Xiong Ding, Zhiheng Xu, Ziyue Li, Xingyu Wang, Hui Zhao, Clifford Otis, Baikun Li and Changchun Liu, Multiplexed Colorimetric Detection of SARS-CoV-2 and Other Pathogens in Wastewater on a 3D Printed Integrated Microfluidic Chip, Sensors and Actuators: B. Chemical, 2021, 344, 130242.

Kun Yin,   Xiong Ding,   Ziyue Li,   Maroun M. Sfeir,   Enrique Ballesteros  and  Changchun Liu, Autonomous Lab-on-Paper for Multiplexed, CRISPR-based Diagnostics of SARS-CoV-2, Lab on a Chip, 2021, DOI: 10.1039/D1LC00293G

Xiong Ding, Kun Yin, Ziyue Li, Maroun M Sfeir, Changchun Liu, Sensitive quantitative detection of SARS-CoV-2 in clinical samples using digital warm-start CRISPR assay, Biosensors and Bioelectronics, 2021, 184: 113218. https://doi.org/10.1016/j.bios.2021.113218

Zhiheng Xu, Kun Yin, Xiong Ding, Ziyue Li, Xuanhao Sun, Baikun Li, Rajesh V Lalla, Robert Gross, Changchun Liu, An Integrated E-Tube Cap for Sample Preparation, Isothermal Amplification and Label-Free Electrochemical Detection of DNA, Biosensors and Bioelectronics, 2021, 186, 113306. https://doi.org/10.1016/j.bios.2021.113306

Uyanga Ganbaatar, Changchun Liu, CRISPR-Based COVID-19 Testing: Toward Next-Generation Point-of-Care Diagnostics, Frontiers in Cellular and Infection Microbiology, 2021, 11: 663949.  doi: 10.3389/fcimb.2021.663949

Karteek Kadimisetty, Kun Yin, Aoife M Roche, Yanjie Yi, Frederic D Bushman, Ronald G Collman, Robert Gross, Liang Feng, Changchun Liu, An integrated self-powered 3D printed sample concentrator for highly sensitive molecular detection of HIV in whole blood at the point of care, Analyst, 2021, 146, 3234-3241

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Contact Us

Professor Changchun Liu

Biomedical Engineering Department

University of Connecticut, UConn Health

263 Farmington Avenue

Farmington, CT 06030, USA

Office:              Room L6083

Phone:             860-679-2565

Email:             chaliu@uchc.edu

Website:          https://smds.engr.uconn.edu/