Welcome to Synthetic Biology and Smart Medical Device Laboratory

Paradigm shifts in biomedical fields often arise from innovations in tools and measurement methods. Our research group is interested in applying interdisciplinary approaches to develop new tools and methods to solve current challenges in life sciences, such as disease diagnostics, medical therapeutics, as well as personalized medicine. Our current research focuses on the integration of micro- and nanotechnology with biology and medicine, and their biomedical applications. Our research philosophy is “Interdisciplinary, Integration and Innovation (I3)”.

We are seeking highly talented and motivated individuals (e.g., postdoc, graduate, and undergraduate) from different disciplinary backgrounds (e.g., biology, chemistry, biomedicine, and engineering (e.g., mechanical, electronic, biomedical). Please see the positions available. We welcome inquiries about positions with a cover letter and CV by contacting Dr. Changchun Liu via email (chaliu@uchc.edu).

Latest Lab News

April 2022: Uyanga Ganbaatar passed her Master defense successfully. Congratulations to Uyanga! We wish her the best of luck in her career journey!

February 2022: Our research work has been featured by Connecticut Post. UConn professor adapts cancer test to detect COVID-19 at home.

February 2022: Our COVID-19 test has been featured by The Daily Campus. UConn researcher working to develop accurate, cheap at home COVID-19 test

January 2022: Our instrument-free, COVID-19 test has been featured by UConn Today. UConn Researcher’s Home COVID-19 Test Comparable to PCR Accuracy, Selectivity

September 2021: Our research project on enhanced N95 mask protection is featured by UConn Today. UConn Health Researcher Focuses on Enhanced N95 Mask Protection.

August 2021: Dr. Xiong Ding, a postdoc researcher at our lab, has accepted a Full Professor position at Southeast University. Congratulations to Dr. Ding! We wish him the best of luck in his career journey!

July 2021: Jiongyu Zhang passed his PhD Qualifying exam. Congratulations!

June 2021: Our article “Autonomous Lab-on-Paper for Multiplexed, CRISPR-based Diagnostics of SARS-CoV-2” has been featured by UConn Today. UConn Engineer Develops Lab-on-Paper SARS-CoV-2 Diagnostic by CRISPR.

June 2021: Our article “Autonomous Lab-on-Paper for Multiplexed, CRISPR-based Diagnostics of SARS-CoV-2” has been featured by News Medical Life Sciences. Scientists develop low-cost lab-on-paper device for rapid and accurate detection of SARS-CoV-2.


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Latest Publications

Naoki Uno, Ziyue Li, and Changchun Liu, Single-tube One-step Gel-based RT-RPA/PCR for Highly Sensitive Molecular Detection of HIV Virus, Analyst, 2023, DOI: 10.1039/D2AN01863B.

Uyanga Ganbaatar and Changchun Liu, NEXT CRISPR: An enhanced CRISPR-based nucleic acid biosensing platform using extended crRNA, Sensors and Actuators B: Chemical, 2022, https://doi.org/10.1016/j.snb.2022.132296

Ziyue Li, Xiong Ding, Kun Yin, Lori Avery, Enrique Ballesteros, and Changchun Liu, Instrument-Free, CRISPR-based Diagnostics of SARS-CoV-2 using Self-Contained Microfluidic SystemBiosensors and Bioelectronics, 2022, 199, 113865, https://doi.org/10.1016/j.bios.2021.113865.

Xiong Ding, Ziyue Li, Lori Avery, Enrique Ballesteros, Rohit Makol, and Changchun Liu, pH-EVD: A pH-Paper-based Extraction and Visual Detection System for Instrument-free SARS-CoV-2 Diagnostics, Advanced NanoBiomed Research, 2021, http://doi.org/10.1002/anbr.202100101.

Jiongyu Zhang and Changchun Liu, CRISPR-Powered DNA Computing and Digital Display, ACS Synthetic Biology, 2021, https://doi.org/10.1021/acssynbio.1c00431

Xiong Ding, Ziyue Li, and Changchun Liu, Monolithic, 3D-Printed Lab-on-Disc Platform for Multiplexed Molecular Detection of SARS-CoV-2, Sensors and Actuators B: Chemical, 2021, https://doi.org/10.1016/j.snb.2021.130998

Zhiheng Xu, Xiong Ding, Kun Yin, Ziyue Li, Joan A Smyth, Maureen B Sims, Holly A McGinnis, Changchun Liu, TickPhone App: A Smartphone Application for Rapid Tick Identification Using Deep Learning, Applied Sciences, 2021, 11(16), 7355

Ziyue Li, Xiong Ding, Kun Yin, Zhiheng Xu, Kumarasen Cooper, Changchun Liu, Electric Field-Enhanced Electrochemical CRISPR Biosensor for DNA Detection, Biosensors and Bioelectronics, 2021, https://doi.org/10.1016/j.bios.2021.113498

Kun Yin, Xiong Ding, Zhiheng Xu, Ziyue Li, Xingyu Wang, Hui Zhao, Clifford Otis, Baikun Li and Changchun Liu, Multiplexed Colorimetric Detection of SARS-CoV-2 and Other Pathogens in Wastewater on a 3D Printed Integrated Microfluidic Chip, Sensors and Actuators: B. Chemical, 2021, 344, 130242.


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Contact Us

Professor Changchun Liu

Biomedical Engineering Department

University of Connecticut, UConn Health

263 Farmington Avenue

Farmington, CT 06030, USA

Office:              Room L6083

Phone:             860-679-2565

Email:             chaliu@uchc.edu

Website:          https://smds.engr.uconn.edu/