Plasma separation from raw whole blood is usually required for blood-based clinical diagnostics. Conventional centrifugation method is not suitable for on-site or bedside applications. To this end, we have developed and demonstrated various centrifuge-free plasma/serum separators based on different separation mechanisms (i.e., crossflow filtration (Fig. A), sedimentation-assisted, size exclusion-based filtration (Fig. B and C)). Our superhydrophobic plasma separator (Fig. C) shows a high plasma yield of above 70% with finger-prick blood (see video). The plasma yield is defined as the ratio of the volume of plasma extracted by the separator (V_separator) and the volume of plasma separated by benchtop centrifugation (V_{centrifugation})). This technology has been licensed to companies for commercialization. We are further integrating our plasma separator with other diagnostic device to develop a fully integrated “blood-to-result” diagnostic system.